Although the SV is quite an interesting concept, and provides an optimal and fair solution for many applications, its main drawback is its computational complexity: the number of computations will increase prohibitively when the number of game players increases.
Notice here that the complexity of these two traditional estimators grows exponentially with the number of unknown DOAs, K, as reflected by the multiplicative term R K. It comes clear now that increasing R (i.e. considering a denser grid search for more refined estimates) increases prohibitively their computational cost.
However, hiring additional nationally certified HIV counselors would have prohibitively increased operational costs for our program, and was determined by the PITC task force to be infeasible at KCH.
We found that MIRA, which is not a de-Bruijn graph-based assembler, exhibited good homoeolog-specificity over a wide range of assembly parameters (Additional file 1: Table S1), without significantly compromising contig length, but at the expense of prohibitively increased memory and CPU-time requirements.
However, use of these newer treatments result in increased toxicities and are prohibitively expensive.
Opponents of smart growth maintain that communities adopting its principles risk exacerbating existing road-congestion problems, unnecessarily burdening mass transit where it is already overused, and prohibitively increasing the operating costs for the private sector, which could induce businesses to relocate to areas governed by more growth-friendly rules.
However, instrumentation can prohibitively increase the time and especially the memory overhead of an application.
We find that a policy that prohibitively increases the cost of 'misdemeanor' types of questionable research practices robustly decreases the overall rate of researcher misconduct, because the rate of 'felonies', such as fabrication, also decreases.
Here we show how to relax this assumption without prohibitively increasing the model complexity.
Affordable assisted living entails prohibitively high costs requiring an increased commitment of public financing.
A: Laser technology is following its own Moore's law trajectory, so in a couple of decades' time we think laser power will have increased sufficiently and such lasers will not be prohibitively expensive.
