The increased peak amplitude in the presence of TTX therefore indicates that GABAA receptor number is increased in layer 5/6 pyramidal neurons, perhaps to counteract a reduction in activity-dependent and -independent vesicular GABA release.
The increased peak b-wave amplitude at high stimulus intensity was significantly larger in the moderate-level than in the low-level GLE group.
We also showed increased peak times and reduced amplitudes of the OPs.
UCn2 gene transfer was associated with increased peak systolic Ca2+ transient amplitude and rate of Ca2+ decline and increased SERCA2a expression.
At intensities lower than 100 dB, the prolonged potential was recorded for both ECochG patterns with increased peak latency and reduced amplitude compared to the compound action potential recorded from the normal control.
For example, we found that UCn2 gene transfer was associated with (1) increased peak systolic Ca2+ transient amplitude and increased rate of Ca2+ decline in cardiac myocytes isolated from HF mice (Fig. 3A D), and (2) increased SERCA2a expression (Fig. 3E) as we previously reported in mice with normal hearts.
SE was defined as repetitive epileptiform discharges with amplitudes >50 μV and a median frequency ≥1 Hz for >30 minutes, producing an aEEG trace exhibiting a sawtoothlike appearance with continuously narrowing bandwidths and increasing peak-to-peak amplitudes or with an abrupt elevation in the aEEG levels from the continuous background pattern.
Consistent with their selectivity, zolpidem increased the peak amplitude and decay time of sIPSCs without affecting RMS noise, whereas THDOC only increased the RMS noise.
In contrast to ambroxol, TTX increased the peak amplitude of the SBAC responses by 15±11% for centrifugal and 29±20% for centripetal stimuli (p = 0.027 and 0.023, respectively, n = 5).
Bath application of CX614 to seven of these neurons significantly increased both peak amplitude and charge transfer by 2.3±0.3 and 4±0.8 fold relative to DAMGO, respectively (Fig 8A, B, n = 7).
