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The increased peak amplitude in the presence of TTX therefore indicates that GABAA receptor number is increased in layer 5/6 pyramidal neurons, perhaps to counteract a reduction in activity-dependent and -independent vesicular GABA release.
Figure 11B and E both appear to show an increased peak amplitude near 1656 cm 1, which further confirms the conversion of β-sheet secondary structure to helical and back.
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Co-expression of SmCavβ increased peak amplitudes to -1640 ± 276 pA (n = 5) and shifted the I V peak leftwards, to +20 mV.
The increased peak b-wave amplitude at high stimulus intensity was significantly larger in the moderate-level than in the low-level GLE group.
UCn2 gene transfer was associated with increased peak systolic Ca2+ transient amplitude and rate of Ca2+ decline and increased SERCA2a expression.
At intensities lower than 100 dB, the prolonged potential was recorded for both ECochG patterns with increased peak latency and reduced amplitude compared to the compound action potential recorded from the normal control.
For example, we found that UCn2 gene transfer was associated with (1) increased peak systolic Ca2+ transient amplitude and increased rate of Ca2+ decline in cardiac myocytes isolated from HF mice (Fig. 3A D), and (2) increased SERCA2a expression (Fig. 3E) as we previously reported in mice with normal hearts.
We also showed increased peak times and reduced amplitudes of the OPs.
Consistent with their selectivity, zolpidem increased the peak amplitude and decay time of sIPSCs without affecting RMS noise, whereas THDOC only increased the RMS noise.
In contrast to ambroxol, TTX increased the peak amplitude of the SBAC responses by 15±11% for centrifugal and 29±20% for centripetal stimuli (p = 0.027 and 0.023, respectively, n = 5).
Bath application of CX614 to seven of these neurons significantly increased both peak amplitude and charge transfer by 2.3±0.3 and 4±0.8 fold relative to DAMGO, respectively (Fig 8A, B, n = 7).
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