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Nevertheless, mitochondrial dysfunction, as it may occur during sepsis, might explain why tissue hypoxia persists in spite of increased oxygen availability [6] (Fig. 1).
Provided that microcirculation is intact, the increase in microcirculatory flow leads to an increased oxygen availability for the tissues, which might be attenuated by tissue oedema.
While increased oxygen availability enhances fetal survival, decreased glucose availability leads to a reduction in fetal growth.
5 Increased oxygen availability in an unlasered retina downregulates VEGF production, inducing regression of retinal neovascularisation (NV).
Also, the increased oxygen availability with high FiO2 levels may lead to induction of cerebral aerobic metabolism, alleviating ischemic injury [ 35, 36].
Invading CTBs respond to this increased oxygen availability by altering the expression of various cell adhesion molecules and proteases, promoting further migration.
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With increasing oxygen availability, ATP production by oxidative phosphorylation is increasingly efficient.
With increasing oxygen availability, succinate is preferentially used as carbon source as it provides additional reductant compared to Malate.
When L. panis PM1 was cultured in 15-ml conical tubes containing 9, 6, and 3 ml mMRS under aerobic conditions (in order to incrementally-increase oxygen availability in the aerobic cultures), the H2O2 accumulation was greatest and most rapid in the 3-ml culture, reaching a maximal value by 12 hours in all samples (Figure 3).
However, despite increasing oxygen availability the glycolytic phenotype persists [21], [24].
Acute blood loss leads to tissue hypoxia, which induces a systemic response designed to increase oxygen availability to the tissues.
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