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In the current study, distractors were associated with increased omission errors and decreased commission errors.
The two levels of connectivity contributed differently to the source-monitoring deficits (Table 2): reduction of inputs to the entorhinal layer led to a drastic reduction in hits, a milder decrease in false alarm rate and a somewhat increased omission rate.
Mice with reduced α7 nAChR expression on a C57BL/6J background strain trained in the 5-CSR task also exhibit increased omission levels [49], [50], suggesting that differences in expression of this receptor in DBA/2J mice may mediate their poor performance in the 5C-CPT.
Both findings, increased omission errors and increased reaction times, are observed when ADHD children are tested on CPTs (Aguiar et al. 2010).
This differs from the findings of increased omission errors on CPTs in ADHD children (Aguiar et al. 2010) and in some lead studies (Chiodo et al. 2004, 2007; Walkowiak et al. 1998).
Under-annotation using Pfam may reflect the increased omission of partial or entire domains due to ORF fragmentation.
Similar(54)
We used this protocol because NK1R−/− mice have previously demonstrated both increased premature responses (an index of one form of impulsivity) and increased omissions (an index of inattentiveness) in this test (Dudley et al., 2013; Yan et al., 2011).
Infusion of the GABAA receptor agonist muscimol into the subthalamic nucleus in rats (a site of Sts expression) produces an array of deficits recapitulating those seen in mice with compromised steroid sulfatase function (i.e., reduced accuracy, slowed correct responses, increased omissions and decreased premature responding) (53).
The 39,XY*O mice, which lack steroid sulfatase expression throughout development, demonstrated impaired 5-CSRTT performance (significantly increased omissions and a nonsignificant trend toward impaired accuracy at short stimulus durations) relative to 40,XY control mice; these deficits were rescued in the 1-CSRTT.
Taken together, these data indicate that the task imposed greater attentional demand at high than low perceptual load conditions, and that distractors significantly decreased and increased commission and omission errors, respectively, at high load, but did not significantly influence either types of errors at low load.
MDMA impaired memory span in a dose-dependent fashion, but impairment was seen only at doses (1.8 and 3.0 mg/kg) that also increased response omissions on both the simple discrimination and the OST.
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CEO of Professional Science Editing for Scientists @ prosciediting.com