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In geriatric patients multimorbidity is linked to polypharmacy, frailty, health service misuse and lack of coordination [ 6], with consequences of increased mortality, frequency of adverse events, reduced quality of life and functional capacity, and stress on health care systems [ 7, 8].
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The increased mortality is largely due to increased frequency of premature cardiovascular disease (CVD) [ 7], which constitutes up to 40% of mortality in RA patients and is as high as that of patients with other major CVD risk factors such as Type 2 diabetes mellitus [ 8].
The frequency and increased mortality emphasizes the clinical significance of polymicrobial bloodstream infections in the neonatal intensive care unit.
Our findings are not consistent with the results of a recent rodent hypoglycemic model study, showing that seizures and especially their frequency were associated with increased mortality [11].
Patient cohorts have uniformly demonstrated that increased intermediate (CD14++CD16+) monocyte frequency is associated with cardiovascular event rate and increased mortality [70,78,93-95].
Thus, the possibility of missing other possible risk factors for increased VAP frequency due to Acinetobacter baumannii or for increased mortality cannot be excluded.
Factors associated with depression in this population include increased frequency and intensity of physical symptoms, lower general well-being, increased mortality and a hastened desire to die [ 5- 8].
The frequency of these findings increases with age [ 4, 5], and in some studies are associated with increased mortality [ 20, 21].
Increased mortality?
As age increased, mortality rate and median LOS increased.
Furthermore, we observed a trend of increasing mortality in patients with the highest frequency (0 vs. 1 to 2 vs. ≥ 3) of hypoglycemia events, irrespective of whether the hypoglycemia was mild or severe (Additional file 2).
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