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Results showed that the younger children initially had higher INS scores than the older kids, but the education program increased INS in both age groups.
Longer days open seems to affect survival more than increased INS.
Even though exogenous PDX1 is not required for the conversion observed here, we found that exogenous PDX1 increased INS expression by two fold.
Chilling and freezing result in the increased Ins(1,4,5) P3–Ca2+ influx [ 67] and transgenic plants overexpressing mammalian 5PTase display a ∼30% decrease in the rapid transient Ca2+ peak in response to cold or salt stimuli [ 61].
The activation of autophagy through a general increase in cytosolic [Ca2+] is therefore not strictly equal to autophagy stimulation via increased Ins(1,4,5) P3R-mediated Ca2+ signaling, and both ways of autophagy stimulation may have different targets (Fig. 2).
Interestingly, the upregulation of autophagy correlated with an increase in the ER Ca2+ content and increased Ins(1,4,5) P3R-mediated Ca2+ signaling.
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