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In evaluating tubulointerstitial damage T2 (>50%) in patients with IgAN, we noted that serum peptides at m/z 5966 and 9289 increased in peak area compared with the other 2 groups (T0, T1).
As shown in Figure 2a-d, urine peptides at m/z 1945, 2392, and 4013 increased in peak area in IgAN patients with S1 lesions, but the peptide at m/z 3389 fell in peak area compared with IgAN patients with S0 lesions.
In urine, peptides at m/z 1945 and 2491 increased in peak area in IgAN patients with T2 tubulointerstitial damage (>50%), but peptides at m/z 1769, 1898, 2977, 3004, 3389, 3406, 4658, and 4752 fell compared with the T0 and T1 groups.
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