Increased heterogeneity of ROS1-rearranged CTCs may result in an increased potential of tumor cells targeted by crizotinib to evolve and adapt in response to treatment.
After 100 days in solution, the nanoparticles exhibited increased heterogeneity due to their inherent instability.
The proportion of high CV values increases with disease advancement (increased heterogeneity of the activity distribution).
Conclusions: Reperfusion microvascular injury was mainly characterized by decreased perfusion velocity and increased heterogeneity.
At the same time, an increased heterogeneity of microvascular flow distribution was also documented.
The variation of pressure gradient around wellbore increases as increased heterogeneity degree determined by different permeability of different plate models.
The size and number of the bubbles increase with an increase in the liquids velocity indicating increased heterogeneity.
Carabid species richness was higher in grazed or sprayed field margins probably due to increased heterogeneity in habitat conditions.
The upper panel shows cell enlargement, vacuolation and an increased heterogeneity after 3 days of treatment with 0.75 mM and 1 mM GO.
Potential reasons for increased heterogeneity might involve the model used and our study design and are discussed in the 'Strengths and Limitations' section.
Higher entropy, lower uniformity, higher standard deviation, higher kurtosis, and positive skewness are thought to represent increased heterogeneity and portend poorer prognosis [2, 3, 4].
