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The majority of studies reported that iron supplementation significantly increased hematologic measures of iron status relative to control.
Iron supplementation significantly increased hematologic measures of iron status (including hemoglobin, hematocrit, serum ferritin) relative to placebo or over time in most studies.
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22 Concurrent administration of Sm-EDTMP with docetaxel was associated with increased hematologic toxicity.
Increased hematologic toxicities have been reported in a recent phase I study of combination therapy involving gefitinib and vinorelbine [ 16].
Increasing dose levels showed increasing hematologic toxicity, but no patient demonstrated neutropenic fever, infection, or hemorrhage.
Exceptions to this are likely the alkylating agents, which seem to increase hematologic malignancy risk, and (in particular) cyclophosphamide, which increases the incidence of bladder cancer.
All but 1 study reported on the effects of iron supplementation on hematologic measures of iron status (Table 3).
While the primary markers for ITP include hematologic measures such as platelet counts, clinical measures typically do not assess a subject's functioning and well-being.
Generalized Estimating Equation models evaluated effect of the food supplementation reduction on hematologic measures and prevalence of anemia, acute respiratory illnesses and diseases of immune system.
Analyses predicting intellectual raw scores from other hematologic measures, adjusted for the same demographic features, were conducted for the subset of 107 children providing blood samples.
A small number of studies included in the systematic review found that iron supplementation had no significant effect on hematologic measures of iron status relative to control.
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