After adjustment for confounders, every 1-point increase in HbA1c was associated with a 14% (adjusted hazard ratio 1.14 [95% CI 1.07 1.21]) increased hazard of developing PDR.
Having a tumour larger than 20 mm at breast cancer diagnosis was still causing an increased hazard of developing first distant metastasis at 10 years (HR=1.5; 95% CI: 1.1 2.0).
For both the primary breast tumour and paired lymph node all subgroups had an increased hazard of developing distant metastases or dying in breast cancer disease, compared with the luminal A subclass (Table 3).
With respect to the WHO staging, being in WHO stage II or higher was associated with an increased hazard of developing TB or death in comparison to patients in WHO stage I at baseline.
Furthermore, patients who were bed-ridden and those with more advanced HIV disease (WHO stage III or higher) at baseline had an increased hazard of developing TB or death in comparison to ambulatory patients or those with early disease stages, respectively.
25 In another large prospective trial with new onset diabetes as a primary endpoint among non-diabetic hypertensive patients, those taking β blockers compared with not taking β blockers had a 28% increased risk of developing subsequent diabetes (adjusted hazard ratio 1.28, 95% confidence interval 1.04 to 1.57).
A multivariable Cox proportional hazards model showed women with a history of GDM had a 26% increased risk of developing hypertension compared with those without a history of GDM (hazard ratio 1.26 [95% CI 1.11 1.43]; P = 0.0004).
Olmesartan initiators had a small but significantly increased risk of developing diabetes after adjusting for baseline characteristics and mean daily dose (hazard ratio [HR], 1.07; 95% confidence interval [CI], 1.03-1.12).
History of previous episode of TB was also associated with an increased hazard of TB (p<0.0001).
However, varenicline was associated with an increased hazard of new psychiatric conditions (hazard ratio 1.18, 1.05 to 1.31).
