Sentence examples for increased hazard of failure from inspiring English sources
We found that patients switching from an NNRTI-based regimen to an unboosted PI-based regimen had increased hazard of failure of second-line cART when compared to those switching to a boosted-PI-based regimen.
In contrast, for the sub-group of patients with a detectable HIV RNA, the HIV RNA level at start of second-line cART led to an increased hazard of failure with borderline significance.
In contrast to 2NRTI+1PI/r, older age, higher HIV-1 RNA, and lower CD4+ counts, an increased hazard of virologic failure was associated with low GSSs of cART, a less recent calendar year, administration of 2NRTI+1NNRTI, and the ART-naïve status.
Multivariable Cox models showed that younger age, lower education, and HIV RNA level were independently associated with an increased hazard of second-line failure among those with documented virologic failure at start of second-line cART.
Patients with the del/del genotype and ARDS also have increased hazard of 60 day mortality and more organ failure.
In fact, both patients with a low-to-nil (score 0 to 1+) expression level of E-cadherin and patients with a high E-cadherin expression level (score 3+) demonstrated an increased risk of failure (respectively, hazard ratio (HR)=1.71, confidence interval (CI =0.72 4.06 and HR=4.22, CI=1.406 12.66) and an interesting association with young age.
We evaluated time from second-line start to virologic failure and factors associated with increased risk of failure using multivariable Cox proportional hazards regression models.
An inexperienced operator significantly increased the hazard of failure.
Of note, positive values of γ k ) suggests that positive values for associated random effects increase the hazard of "failure", while negative values of γ k ) suggest that the positive values for the random effects decrease the chance of experiencing the event of interest.
This finding is consistent with that of Mitnick C, et al. where low haematocrit was associated with about 4 times increase in the hazard of failure or death compared with normal haematocrit [ 18].
