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PAS scoring of goblet cells showed a trend toward increased grades in the older OVA group than in the young OVA group, although only the 6-month group had a statistically significant difference compared with the young OVA group (6-month-old mice, 3.00 ± 0.17, versus 6-week-old mice, 2.20 ± 0.24, P < 0.05).
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Likewise, pairwise posttest comparisons revealed histological intergroup differences for DJD grades (p = 0.025), with increasing grades in the HIMP group as compared to controls (controls versus HIMP ; Table 2).
Expression increased with increasing grade in CIN.
In this study, we confirmed the expression of miR-181b decreases with increasing grade in gliomas.
MUC4 is expressed by metaplastic ducts and its expression increases with increasing grade in pancreatic intraepithelial neoplasias (Swart et al, 2002; Park et al, 2003).
There was also significant enrichment of the proliferation signature with ER-positive tumors of increasing grade in all pair-wise comparisons.
25This is consistent with arguments that the state's research universities have tougher grading standards than other institutions and may have increased grading standards in STEM fields post-HOPE.
Compared to BLOKS, the new measure of BML volume increased across grades in the tibia, with the exception of between grades 2 and 3.
This would strongly suggest that senescent cells are indeed present in increasing number with increased Banff grade, in line with our observations of p21WAF1/Cip1.
In contrast, the proportion of CD166+ cells increased with increasing OARSI grade in the surface and middle zones (p = 0.005 and p = 0.001) (Table and Supplementary figure).
Fyn expression was found to significantly increase with increasing histological grade in both peripheral chondrosarcoma (P=0.05 Pearson chi-squared test) and central chondrosarcoma (P=0.000, Pearson chi-squared test).
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