To further determine whether the increased protein levels of c-Jun were due to increased gene expression, we examined the mRNA levels of c-jun in nine patients with schizophrenia and nine control subjects by relative RT-PCR.
At specific promoters, hydroxymethylation correlated with increased gene expression.
The loss of PTPRS, however, brought about increased gene expression in both cell lines regardless of KRAS mutation status.
Using quantitative RT-PCR, we confirmed increased gene expression in vivo for a subset of these genes.
Increased gene expression of antimicrobial peptides (BNBD4, DEFB10, and DEFB1) occurred on the day of calving.
Increasing the histidine residue from 0 to 5 to 10 further increased gene expression efficiency.
This could be partly related to the increased gene expression of PPARγ in muscle tissues.
A minimal model correctly predicts the increased gene expression variability across mutants.
We show experimentally that these mutations increase fitness by an amount comparable to non-synonymous mutations and that the fitness increases stem from increased gene expression.
As we expected, transfection of NICD increased gene expression levels of Hes-5 and Hey-1, which are the target genes of NICD.
Nevertheless, it is possible that a histone H2A.Z depletion drives gbM (Bewick et al. 2016) and an increased gene expression consistency (Coleman-Derr and Zilberman 2012).
