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The higher slope of the EMG force relation in POST than in ANT is interpreted in terms of increased gain of the excitatory drive-firing rate relation.
This results in greater precision for the respective representations (predictions), resulting in increased gain of their prediction errors.
An increased gain of gene copy number was associated with a worse PCa-specific survival and suggested a possible role of early total androgen ablation [ 30].
Our results thus identify a muscle-specific role of TDP-43 in Drosophila and show that lowered (RNAi knockdown) or increased (gain of function) levels of TBPH protein can cause pathogenic phenotypes that resemble characteristic features of ALS and FTLD.
As suggested by Larsson & Smith (2012), increased responses for unpredicted stimuli could reflect an increased gain of prediction error for the unpredicted input, leading to an orienting response towards unexpected events in the environment.
This was accompanied by an increased gain of grip strength of 0.68 kg (−0.11 kg to 1.46 kg) for the whey supplement group and 0.93 kg (0.16 kg to 1.70 kg) for the soy supplement group.
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This pattern strongly supports the idea that HD pathogenesis results from a combination of increased gain-of-function of the mutant HTT together with the decreased wild-type HTT physiological function.
These increases in allele frequencies with age also illustrate the increasing gain of power conferred by studying centenarians and even more so, subjects age 105+ years, in genetic studies of exceptional survival.
All the proteins show an increasing gain of α-helicity upon addition of TFE, as indicated by the characteristic maximum at 190 nm and double minima at 208 and 222 nm (Fig. 8).
Increased center-surround antagonism, indicative of increased gain control, has also been found in motion studies in schizophrenia (34).
To achieve the increased gain, we preferred the use of cascode OTA.
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