Activation of hM3D(Gq) leads to depolarization and increased firing in infected neurons, while the activation of hM4D(Gi) induces a hyperpolarization of neurons.
The researchers speculate that increased firing during seizures creates too much noise for the coordinated action of astrocytes--and perhaps decreases their efficiency in sopping up neurotransmitters.
The current input and increased firing rate triggers dynamic facilitation through equations (11 13).
Our data from in vivo activity-blockade in the hippocampus, demonstrating enhanced input resistance and increased firing to depolarizing current inputs, generally agreed with these prior observations.
Had we presented stimuli with comparable amplitude modulations, leading targets might have evoked increased firing throughout the superposed portions of our stimuli as delay was increased.
Another mechanism involves increased firing of place cells.
Increasing the primary cluster to 10 units increased firing rates for suprathreshold stimuli by 20%.
Pre-treatment with BoNT-A prevented IS-induced increased firing in C- but not Aδ-units.
Note however, that even in the penumbra, there is typically increased firing over baseline activity levels (Schevon et al., 2012).
Our electrophysiologic data demonstrate that, soon after injury, RGCs display increased firing rates characteristic of hyperexcitable neurons.
Of 272 single units isolated from seven mice, 161 responded to the flash with, in all cases, increased firing.
