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The "one drug, one target, and one disease" model is partially contributing to the increased failures of clinical trials due to its lacking consideration of side effects or toxicities in the early stage of drug discovery and development.
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One reason for the increased failure rate, Mr. Garmaise said, could be the pace at which loans are underwritten.
Increased failure rates were seen at the proximal tibia prosthesis.
Interestingly, several studies suggest increased failure rates of miniscrews in younger adolescent patients.
Synergetic strengthening and stiffening effects can be achieved in overall rachis owing to increased failure resistance.
Gitelis et al. [9] have also shown increased failure rates to be associated with proximal tibia prostheses.
As the amplitude of out-of-straightness increased, failure load always reduced, weather governed by global buckling or skin wrinkling.
The new switches have been a headache for the company since they were launched back in 2016, including reports of increased failure rates and the looming specter of class action suits.
In simulated driving experiments, high doses of stimulants have been associated with driving impairments, including increased failure to stop and signal violations (Silber et al. 2005).
The sample #2 and its fragments were repeatedly loaded three times, with higher breaking force required for each successive test as well as increased failure strain.
HS increased failure temperatures compared with CON, and ouabain decreased failure temperatures in CON but not HS preparations (post hoc Tukey tests, P<0.05).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com