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Notch3 in complex with either EDTA or an activating antibody resulted in increased deuteration, signifying increased dynamics whereas binding of an inhibitory antibody reduced deuteration.
De Biasio, A. et al. Reduced stability and increased dynamics in the human proliferating cell nuclear antigen (PCNA) relative to the yeast homolog.
However, they also suggest that increased exposure of the 509 511 loop and increased dynamics in its vicinity could promote aggregation in vitro and aberrant intermolecular interactions that impede trafficking in vivo.
Our findings point to increased dynamics and a departure from a lamellar behavior for DPPC on addition of the peptide, consistent with our observations of DPPC phase separation in native surfactant.
The increased dynamics of hPCNA relative to scPCNA may allow it to acquire multiple induced conformations upon binding to its substrates enlarging its binding diversity.
The increased dynamics might enhance or inhibit the binding ability of PrPC with other chaperones, which would exert profound influence on prion conversions.
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SDH/SONET-WDM multi-layer networks are a very attractive solution to cope with the increasing dynamics and capacities in today's core networks.
Companies today find themselves in global competition with ever increasing dynamics and a complexity of framework requirements, processes and products.
In lag1, the genes needed to utilize the specific carbon source in the medium (arabinose) are expressed with exponentially increasing dynamics, despite the fact that biomass does not measurably increase.
The increasing dynamics of the health workforce – through mobility [ 12], reduction of working hours, the ageing workforce, increasing number of female physicians, changing division of labour – implies that projecting the future workforce could become more difficult [ 13- 16].
When arabinose is the sole carbon source, the vast majority of promoters are inactive in lag1, except for the promoters for the carbon source in the medium (arabinose) which are activated with exponentially increasing dynamics.
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