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Using the power law expression (Mt/M∞ = ktn) it became evident that the inclusion of acids increased drug release.
A statistically significant difference was seen for varying concentration of the polymer (lower concentration leading to increased drug release) for all the three polymer series.
The increased drug release was observed when a greater in drug solubility and a decrease in the molecular weight of drug were applied.
Leaving the carboxylate of HA chain unaffected, the conjugate with drug loading as high as 21.8% showed an excellent water solubility of 168 mg/mL and exhibited increased drug release in the presence of hyaluronidase.
Thus increased drug release in pH 1.2 could be explained by the prevention of gel formation of xanthan gum.
For example, increased drug release at acidic pH can target a drug to a cancer tumor where the pH often is more acidic.
Similar(52)
Increasing pore former level and decreasing coating level were found to increase drug release rates.
Xanthan gum, a hydrophilic polymer, was added to the formulation to increase drug release.
Increasing coating solution feed rate and decreasing fluidizing air temperature were found to increase drug release rates.
The micro-porous structure helps to increase drug release rate due to a shorter diffusion path of the drug in the polymer.
The effect of vitamin E loading an established procedure for increasing drug release time in other commercial lenses, was also tested on the release of timolol maleate and levofloxacin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com