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Mice were subjected to an increased dose of nebulized methacholine (MCh) challenge protocol using an in-line ultrasonic nebulizer.
(I) Mice were subjected to an increased dose of nebulized methacholine (MCh) challenge protocol to assess features of respiratory mechanics.
Mice were subjected to an increased dose of nebulized methacholine (MCh) challenge protocol to assess characteristics of respiratory mechanics in HDM (A) and OVA model (B).
It is reported that spermine induces caspase 3 activation and triggers cell death through evoking cytochrome C release from mitochondria.34 In our preliminary study, prolonged incubation or increased dose of spermidine also resulted in caspase 3 activation and subsequent cell death (data not shown).
The results showed that an increased dose of PMSG injection significantly increased the numbers, total diameters, and diameter of each dominant follicle and corpus luteum, as well as serum estradiol and progesterone concentrations (P < 0.05).
Moreover, no patient had a trial of an increased dose of previously effective drugs.
I postulate that the negative outcomes of these studies are related to the fact that the increased dose of protein/amino acids were given as a continuous infusion.
In contrast, cells receiving an increased dose of paclitaxel that induced G(2 -M arrest, but not apoptosis, only exhibited the early change in subcellular structure but did not show the later change associated with changes in nuclear substructure.
Given the study design, the effect of an increased dose of vaccine (30 µg of each antigen) could be assessed and compared to standard dose (15 µg of each antigen) at week 4.
Spirometry was repeated 3 min after each increased dose of methacholine.
This increased dose of dipyridamole had demonstrated increased anti-inflammatory effect in some models.
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