Potential disadvantages of IMRT include increased risk for a marginal miss due to sharp dose drop-off, increased dose inhomogeneity, increased integral dose, and increased costs.
Firstly, the dose delivered per cycle can be increased (dose intensity), secondly, the dosing interval can be reduced keeping the dose per cycle and overall dose the same (dose densification), and finally both the dosing interval can be reduced and the overall dose increased (increased dose intensity, total dose, and dose density) [ 9].
Linear regression analysis indicated that PFOA concentrations among the dose groups increased dose dependently (r = 0.7711).
This local control was attributable to improved tumour target coverage, increased total dose and increased dose per fraction to the tumour target.
Results from a retrospective study suggest that regimens with an increased dose per cycle (dose intensity) of anthracyclines (Thor et al, 1998) are associated with an improved outcome only in women with HER2 overexpression.
The observed maximum serum concentration after each dose increased slightly from dose 1 through dose 3 at all dose levels, consistent with an accumulation ratio of 1.4 to 1.7 for area under the curve.
Daily treatment with teriparatide at both doses increased, dose-dependently, lumbar spine and femoral neck BMD (Table 2).
Given the low responses seen in relapsed disease, increased dosing and dose escalation have been evaluated as strategies to increase response to rituximab (Byrd et al, 2001; O'Brien et al, 2001).
Pharmacokinetic parameters were otherwise similar to that previously reported in the same populations [ 2]. > -wrap-foot> Thistudydy evaluated the use of an increased AS dose and an increased dosing frequency (ie, a split dose) in uncomplicated falciparum malaria with varying degrees of resistance to artemisinins.
