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TLD studies of the extracted metallic port revealed highest doses within the casing of the metallic port and no consistent increased dose at the surface of the expander.
The tumour control rate was 80% for the 10 patients who received an increased dose at cycle 2, and 67.9% for the remaining 28 patients.
The median TTP for the 10 patients who received an increased dose at cycle 2 was 4.1 months; the median TTP for the remaining 28 patients was 2.8 months (hazard ratio: 0.91, 95% CI: 0.41 2.04, P=0.833).
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Although the intensities of the crystalline reflections diminish with increasing dose, at 260 MGy the scattering curves appear only slightly changed from those of the unirradiated material.
Quantitative analysis showed no significant change in the average size (∼3 4 nm) and distribution of defect clusters with increasing dose at 50 K and 473 K.
It should also be noted that in the T98G cell line, GNP DEFs appear to decrease with increasing dose; at 8 Gy the DEF decreased to 1.35 ± 0.03, suggesting GNPs are not solely acting as a dose modifying agent as DEFs would be expected to be uniform across all doses in this case.
If, however, the SST is failed, we would normally initiate hydrocortisone replacement therapy with appropriate 'sick day rules' with regards to increasing dose at times of stress or inter-current illness, provide the patient with information and a 'steroid card' and perform repeat testing after 3 6 months.
There was a significant dose response for EPA, DHA, and EPA plus DHA in all sample types (with the single exception of erythrocyte EPA, for which there was a strong trend for a dose response), and there was a clear linear trend of increasing EPA and DHA with increasing doses at 12 mo.
Moreover, HEY2 increased dose dependently with thiocoraline treatment at protein level.
ROS generation and mitochondrial depolarization increased dose-responsively at high concentrations but showed minor changes at low concentrations of GSE in Ca9-22 cells.
There was also an increase in succinate and a decrease in adenosine with increasing dose of PB at all time points.
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