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Prolonged delivery of BDNF resulted in a dysregulation of plasticity-related functions: increased dose and duration of BDNF delivery produced increased levels of TrkB, ERK, CREB, and phosphorylated ERK, while also producing decreased phosphorylated CREB.
Increased dose and duration of NMBA is associated with significant morbidity [25 27, 29], so it is in the patient's best interest to given the least amount of NMBA possible.
We detected a statistically significant linear trend between the increased dose and hospitalization related to liver injury (Table 2).
The patient's symptoms gradually improved with this increased dose and his lymph nodes and abscesses began to decrease in size.
In mice with murine L1210 leukemia, the activity of 5-AZA-CDR markedly increases with an increased dose and exposure time [ 60, 61].
Increased dose and duration of NMBA is associated with significant morbidity [ 25- 27, 29], so it is in the patient's best interest to given the least amount of NMBA possible.
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Tolerance is particularly troublesome as this leads to increased dosing and more side effects.
Additional clinical trials are now testing increased doses, and no new toxicities have been observed to date.
** Quinapyramine is too toxic at increased doses and therefore does not figure in the second half of the table.
There appears to be a heightened risk of antibody formation with increased doses and frequency of administration.
In general, it is important to cover the whole day by the increased dosing, and not to just double the dose in the morning.
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