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Being in the Part D gap period increased discontinuation risk: HR = 1.09 (95 % CI: 1.03, 1.16).
We previously showed increased discontinuation rates of efavirenz due to CNS toxicities in Malay and Chinese patients in our Treat Asia HIV Observational Database (TAHOD) database.
The occurrence of grade 3/4 LDAEs was not independently associated with increased discontinuation rates, an observation in agreement with the recent publication of the UK Register of HIV Seroconverters [21].
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Long term triple antiplatelet therapy was asociated with a significant increase in adverse events and bleeding rates, and their severity, and a trend to increased discontinuations.
On the other hand, the complicated setting of a trial that uses a double-blind, double-dummy design may also have an impact and may actually increase discontinuation.
It may represent either increasing discontinuation rates over time, perhaps because of adverse events with active therapy, or patients who had previously achieved a response at a given level now experiencing a decrease in their magnitude of improvement to below the level in question, or some combination of these.
Oxygen saturations significantly decreased during HFCWO and significantly increased after discontinuation of treatment.
Reaching performance increased upon discontinuation of the antagonists and reached the level of controls within three days.
BTM levels increased upon discontinuation and decreased with retreatment.
The indices demonstrating disease activity increased after discontinuation of the antibiotic treatment.
We also examined whether thyroid volume increased after discontinuation of sunitinib.
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