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Consistent with this possibility, the overall balance of microtubule-associated proteins, destabilizing factors, and inhibitors of microtubule assembly suggest an increased destabilization of microtubule assembly, which is potentially linked to an increase in the stability of cell structure and a decreased ability to initiate neurite extension.
More to the point, Our presence in Afghanistan has only increased destabilization and insurgency in Pakistan.
Our presence in Afghanistan has only increased destabilization and insurgency in Pakistan where we rightly fear a toppled or weakened Pakistani government may lose control of its nuclear weapons.
Hyperphosphorylation at both Ser262 and Ser396/404 has been shown to lead to reduced binding of Tau to microtubules resulting in increased destabilization of the microtubules [41] and, ultimately the collapse of the cytoskeleton.
The diffuse mitochondrial signal in immunocytochemistry supports the possibility of increased destabilization of this variant that might lead to the selective purification of heteromultimers containing wild-type Twinkle.
Our direct comparison between DNA/DNA and RNA/DNA hybridization on microarrays reveals – for RNA/DNA duplexes – an increased destabilization of purine-purine mismatches, with respect to other MM types.
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After destabilization, M23(C, B 6 secondary borocarbide with a specific orientation relationship precipitates first and thereafter coarsens following the appearance of M7(C, B 3 precipitation with the increasing destabilization temperature at the same soaking time, thus leading to a large decrease of Cr content in the martensite.
These effects are, on the one hand, increasing stabilization due to a higher concentration of stabilizing end groups and, on the other hand, increasing destabilization due to the increased ionic strength in the continuous phase.
This result is similar to that caused by truncations in the synaptobrevin C-terminus and can thus be attributed to increasing destabilization of the CpxI central helix as more residues are deleted in syntaxin-1 (the effects are smaller because most of the residues deleted in syntaxin-1 do not contact CpxI[26-83] CpxI[26-83]igure supplement 1).
Reduction of Stat3 in NIH3T3 foci is related to increased microtubules destabilization, as indicated by reduced acetylated α-tubulin and transformed cell morphology.
Despite the popular assumption that MMPs promote tumor invasion and growth, a recent study revealed that MMP2 overexpression in astrocytoma cells inhibited tumor growth and increased vascular destabilization [ 44].
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