Sentence examples for increased deletions from inspiring English sources

It appears that mutational bias is one cause of these increased deletions.

We find that depleting SETD2 generates a mutation signature resembling RAD51 depletion at I-SceI-induced DNA double-strand break (DSB) sites, with significantly increased deletions arising through microhomology-mediated end-joining.

Moreover, genome-wide association studies (GWAS) of schizophrenia have identified a number of risk genes (e.g., DISC1, COMT), single-nucleotide polymorphisms (SNPs), rare de novo copy number variations (CNVs), and increased deletions and/or duplications at coding regions.

Short direct repeats, tandem repeats and monotonic runs are known to promote strand misalignments during DNA replication and might explain the increased deletion frequency we observed in the H. salinarum NRC-1 pyrE2 gene [35].

In the adult male HY-TCR thymus, clonal deletion is efficient and complete, and so we could not test if reduction in Shh copy number increased deletion.

Recently, association studies have suggested a negative correlation for inverted complementary repeat sequences in mtDNA in maximum life span across species, possibly through increased deletion mutagenesis [ 42].

Dai and colleagues previously have reported an increased deletion rate (58%) of one NHERF1 allele and also mutation with loss of heterozygosity in 3% of breast cancer cell lines and primary tumors [ 4].

Specifically, as a tissue ages and accumulates deletions, it is unknown whether this increased deletion load arises through clonal expansion of an existing pool of mtDNA deletions (early acquisition), continual accumulation of new mutations (late acquisition), or an equilibrium of both processes (Khrapko, 2011).

Additionally, with increasing deletions of large numbers of predator species and additions of planktivores, the likelihood of gaining or losing species with a particularly strong effect on ecosystem function increases.

When using increasing deletions of the Pol III tail, Pol IV can access the clamp again.

In conclusion, the gradual loss of affinity with the increasing deletions of the tail clearly indicates that the tail of Pol III has multiple interactions with the clamp, with the exonuclease providing an additional contact.