Sentence examples for increased current amplitude from inspiring English sources

Interestingly, the mutant M132T exhibited significantly increased current amplitude (Figure 2C).

Although LLZ expressed either alone or with CHEB42A did not generate ion channel currents, CHEB42A increased current amplitude of another DEG/ENaC protein whose ligand (protons) is known, acid-sensing ion channel 1a (ASIC1a).

Four of the previously reported TRPC6 mutations (P112Q, R895C, E897K and Q899K) also showed gain of function in channel peak activity, leading to an increased Ca2+ influx and increased current amplitude upon activation [9], [10], [12].

The KCNQ activator flupirtine (20 μM) increased current amplitude across the voltage range.

MFA (20 μM) significantly increased current amplitude at +40 mV (n = 11, P < 0.05; Figure 6E, F).

Calcium is a permeant blocker of the transducer channel (Ricci & Fettiplace, 1998; Marcotti et al., 2005), so the increased current amplitude in low Ca2+ is caused by the partial relief of this block.

KCNQ3 (alsoS) also yielded greatly increased current amplitudes, whereas currents from mutant A315V channels were very small.

One consequence of reduced inactivation would be increased current amplitudes; however, the effect of (S -2 on the current amplitude of Kv7.4 waS -2ch larger than what can be acconnthe for by reducurrentctivamplitudene.

Mutation of the di-leucine motif to aspartic acid greatly increased current amplitudes without affecting the physical interaction with stomatin.

Functionally, the identified non-synonymous mutation p.Gly88Arg that is located in the first extracellular loop of TASK-4 resulted in threefold increased current amplitudes by an altered gating behavior which was conferred to wild-type channels in a dominant-active manner.

Stimulation (hash marks above traces) before and after electrode displacement and axotomy was done with 1 Hz TTL-stimulated current pulses (120 µs, increasing current amplitude every 10 s for 0.2, 0.8, 1.6, 3.2 mA) with the final 1Hz TTL stimulation at 3.2 mA lasting 14 s for the control trace (dark blue hash marks).