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Increased copy number of a BAC transgene correlates with increased expression of the BAC transgene (Chandler et al. 2007).
EGFR amplification and/or increased copy numbers have been reported and range from 4.5%to30%0%.
FISH and real-time PCR analysis identified cell lines with reduced or increased copy number spanning the entire parkin locus.
Humans, for example, only had 84 genes with increased copy numbers over those of our closet relatives.
Increasing levels of wheat linearly increased copy numbers of 16S rRNA for total bacteria (P=0.01) and Ruminococcus amylophilus (P=0.04) per g of rumen contents.
The improved lactose fermentation by the EJ2e8 strain was due to the increased copy number of cdt-1 and gh1-1 genes.
An increased copy number of these genes is therefore not the basis for the hypermethylation commonly observed in this premalignant lesion.
Many of these regions also show some evidence of increased copy number in humans, although they have not been previously classified as duplications (fig. S22).
The increased copy number plasmid yielded fewer coloured colonies than the wild-type plasmid.
Heightened expression of EEF1A2 was not associated with increased copy number or coding sequence mutations.
PDGFRα, a well known oncogene, displays increased copy numbers in different tumor entities including glioblastoma [3], [12].
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