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We hypothesized that increased conversion of this prodrug to its active metabolite (SN-38) at tumors sites would increase selective antitumor activity.
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Indeed, kinetic analysis of cells following exposure to Os showed increased conversion of the cytosolic form of microtubule-associated protein 1 light chain LC3-I into LC3-II by western blot analysis (Supplementary Figure S2A).
As a consequence of this glucocorticoids-dependent enzyme activation there is increased conversion of C19- to C18-steroids, so that maternal progesterone levels fall and oestradiol levels rise [ 8].
This was accompanied by an increased conversion of 6-APA to ampicillin as well as a decreased undesirable hydrolysis of the acyl donor.
When propyne and butane were co-fed over the catalyst there was a synergistic effect resulting in an increased conversion of propyne (81 cf. 26 % when fed alone); however, much of this increased conversion was converted to carbon deposited on the catalyst.
Furthermore, the increased conversion of peripheral androgens in estrogens mediated by aromatase is confirmed in this study.
This lack of association may be due to increased conversion of androgens to estrogens in RA, which exert proinflammatory activities by estrogen receptors.
The several types of NPs are described, which provide significant increased conversion of laser pulse energy in PT/PA phenomena.
This is due to the speedy desorption of the alkylated product from the catalyst surface as the temperature increases which facilitates the further adsorption of reactant molecules, resulting in the increased conversion of BC.
These microdevices have been successfully applied in the synthesis of biodiesel, mainly due to increased conversion of reactants in a short residence time.
Increases in body fat may directly affect the hormonal regulation of puberty; increased aromatase activity, and thereby increased conversion of androgens to estrogen may promote earlier breast development [49].
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