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Exact(8)
Administration of nebicapone by the intraperitoneal route significantly increased compound AUC in the rat while in the mouse a significant increase in AUC of metabolites was observed.
This discrepancy may be due to increased compound:tubulin ratios in cells.
Furthermore, the DMSO included in the qHTS assay may have increased compound concentration to the point where 1-AMA displacement could be observed.
For the primary screen, the compounds satisfying the criterion of z-score >2 or <−2 were subjected to a secondary screen at an increased compound concentration of 200 uM (10∶1 molar ratio to heme).
The secondary screen consisted of repeating the heme interaction assay using an increased compound concentration of 200 uM (10∶1 molar ratio to heme) and the compounds with greater than a 10% A415 reduction were selected for further absorption spectral and cytotoxic analyses.
The overall LY2140023 exposure-adjusted rate of seizures had decreased substantially with the increased compound exposure in the current 24-week HBBR study and in other ongoing studies.
Similar(50)
Generally, the dot product kernel results in larger similarity values with an increasing compound or fingerprint size.
Random deletion of bits that are set on in complex templates has been shown to increase compound recall, despite the associated loss in chemical information content [6].
With increasing compound coverage, the fraction of scaffolds involved in both scaffold hopping and activity cliff formation significantly increased to more than 50%.
HaCaT cells were incubated with increasing compound concentrations (3.2 nM – 50 µM) for 24 h.
Also, with added noise, sigmaf changed more gradually with increasing compound sigma compared to the abrupt changes measured with noise free compounds.
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CEO of Professional Science Editing for Scientists @ prosciediting.com