Sentence examples for increased circulation time from inspiring English sources

To utilise PEG for increased circulation time, the ratio of PEG to targeting ligand has to be optimised.

The main goals of these vehicles are to provide improved drug disposition Putney (1998), protection from metabolic degradation Dziubla et al. (2005), and increased circulation time Putney (1998).

Phosphorothioate ONs bind serum proteins, leading to reduced renal clearance and an increased circulation time.

Reversible or irreversible covalent attachment of polymer to small molecule non-peptide drugs can result in reduced metabolism, increased circulation time, improved activity and reduced toxicity.

Pharmaceutical vehicles can serve several different purposes during delivery of active substances, such as extended release, increased circulation time, or protection against degradation.

Addition of chemical crosslinking agents such as glutaraldehyde gives gelatin stability, shape, and increased circulation time in vivo as compared to unmodified gelatin.

Proof-of-concept studies have demonstrated the potential for NDD systems to simultaneously achieve reduced drug toxicity, improved bio-availability, increased circulation times, controlled drug release, and targeting.

The temperature of the upper part of the wellbore increases with the increasing circulation time and drilling displacement, and the lower part of the wellbore decreases with the increasing circulation time and drilling displacement.

The most broadly used polymer is polyethylene glycol (PEG), which reduces their uptake by the reticuloendothelial system (RES) and increases circulation time when compared with uncoated counterparts [9 11].

The use of polymeric coatings can also lead to other key benefits, such as increasing circulation time, improving bioavailability of encapsulated drug, increasing targeting efficiency, and altering surface charge of the liposomes [49].

One area to investigate is whether or not the strength of binding to plasma protein, while increasing circulation time, may show an inverse relationship to toxicity, given the lack of residence time in target organs.