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The condition appears to be associated with defects in the mechanisms that regulate the growth and production of cells in the brain, resulting in increased cell size and cell number.
Increased cell size was found to reduce KIc, especially at the lowest crosshead rate.
Increased cell size and irregular cell shape might be associated with the dense cytoskeleton organization, which could lead to an increase in both stiffness and viscosity.
hiPSC-CMs harboring the R9C PLN mutation showed activation of a hypertrophic phenotype, as evidenced by expression of hypertrophic markers and increased cell size and capacitance of cardiomyocytes.
In contrast, the cells exposed to >9 µg/ml concentration of gentamicin and >16 µg/ml of CuNPs for 24 h showed increased cell size and change in cell shape (Fig. 4b).
This network identified a number of genes that could contribute to increased cell size (Fig. 3B).
Indeed certain elements of the ept mutant phenotype (e.g. increased cell size) do not appear to respond to reduced DaPKC activity.
Nonetheless, both alleles increased cell size in MCF7 cells (data not shown) and reduced susceptibility to lapatinib in SKBR3 cells (Figure 3B).
The results of these analyses suggest that change in fatty acid composition and increased cell size might be the typical phenotypes of ethanol-adapted yeast cells.
Rather, they cause an increased cell size and aberrant cell morphology that are dependent upon inhibitory phosphorylation of Cdk1 at the G2/M transition.
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At the cellular level, increased cell-size and enhanced protein synthesis are the prominent characteristics [ 5].
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