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In injured A-type DRG neurons, the average current density of INaP was also significantly increased (CCD group: 2.8±0.3 pA/pF, control group: 1.6±0.3 pA/pF, non-paired t-test, P<0.05; Fig. 4A 4C).
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DHA consumption increased CC (↑12%) and decreased F-I slopes (↓21%), thereby preventing the opposite alterations observed in 3xTg-AD mice.
One patient developed myocardial infarction in addition to increased CC-IMT, two patients suffered from angina pectoris, and one of these patients also had increased CC-IMT.
When comparing the EO to the LO mTLE, the highest CC differences involved increased CC for the EO relative to the LO group.
For instance, TLE patients with an early onset showed increased CC in the PCC, relative to controls, regardless of lesional status.
Furthermore, these results also indicate that the elongation of polyA repeats leads to an increased CC stability, as shown by the similar behavior of ccA21 and ccAL peptides.
Five of the nine patients who developed clinical macrovascular events also had increased CC-IMTs and/or AS plaques in the common carotid arteries.
Our data also provide evidence of increased CC in all groups relative to controls emerging from the non-ictal temporal lobe, with this effect most prominent for early onset patients.
An alternative possibility is that increased CC in this specific region serves an adaptive purpose in EO patients, as the PCC has been described as one of the major hubs in the brain for cognitive processing (Buckner et al. 2009), resting-state activity (Fransson and Marrelec 2008), as well as a crucial structure for maintaining an inhibitory surround in unilateral, focal TLE (Tracy et al. 2012).
The LRS decreases with increasing CCs.
(b) LRS decreases with increasing CC from 10 to 200 μA, whereas HRS remains unchanged.
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