Both decreased bone formation and increased bone resorption (in different amounts) are observed.
Dysregulated inflammation leads to increased bone resorption and suppressed bone formation.
These data are the first to suggest a relationship between DHEAS and increased bone resorption in AN.
Increased bone resorption, and probably decreased bone formation are involved in the process of bone lesion caused by iron overload.
Synthetic analogues of calcitonin are of particular interest in the treatment of osteoporosis, a disease characterized by the thinning of bones that arises from increased bone resorption or decreased bone formation.
Low cytokine levels suggest that these factors do not mediate the increased bone resorption of AN. (J Pediatr 2002 141 64-70).
Postmenopausal osteoporosis is a condition associated with low bone mass resulting from the increased bone resorption that occurs following a decline in estrogen levels.
In patients suffering from this disorder, PAP activity contributes to increased bone resorption and, therefore, human PAP is a key target for the development of anti-osteoporotic drugs.
Mean urine hydroxyproline and calcium levels were elevated at enrollment, suggesting increased bone resorption; the mean values decreased to the high normal range at follow-up.
Immobility, causing a reduction in BMD due to increased bone resorption, is a moderate risk factor for fragility fractures, with a relative risk of 1.5 2.
Another study reported an increased bone resorption rate (27.9 %) on pre-operative radiation therapy patients after non-vascularized iliac bone graft [15, 16].
