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In a recent note Espirito Santo set a price target of 635p, but said that could be underestimation given the prospect of stronger UK economic growth boosting the business, as well as increased benefits from its efficiency drive.
Living in social groups provides several benefits such as better defense of food resources, less predation pressure and increased benefits from pooling information [1], [2].
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It is not clear how these effects would translate into increased benefit from IIT.
ER-negative tumors exhibited significantly increased benefit from the above preoperative regimens compared to ER-positive tumors.
Several explanations for the increased benefit from tamoxifen in patients who carry a CYP2C19*2 allele can be considered.
Predictive biomarkers, or responder identification biomarkers, are molecules or other characteristics of a patient or a patient's malignancy that predict increased benefit from a particular drug.
In this study, we have shown a trend towards significance for an increased benefit from the addition of anthracycline in patients with high CIN.
These data correlate well with the clinical studies demonstrating increased benefit from tamoxifen therapy in those patients whose tumors are ERβ positive and suggest that this benefit may be through the actions of endoxifen.
Results from a retrospective phase III clinical trial conducted by the National Cancer Institute – Canada Group also confirm that Topo2 α protein overexpression might be associated with increased benefit from doxorubicin (hazard ratio 1.09, 95% CI: 1.03 1.15, P=0.002) (Durbecq et al, 2004).
Since we hypothesize that tumors from women with a CYP2C19*2 genotype are highly dependent on estrogen signaling, we expect an increased benefit from aromatase inhibitors as well in these patients.
In the pre-planned treatment-by-marker analysis, there was a significant interaction between HER1 3 expression and treatment (HR=0.58; 95% CI, 0.39 0.87; P=0.008) in favour of increased benefit from exemestane in HER1 3-negative patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com