Exact(1)
Although the efficiency of binding-sites prediction for unbound chains has been significantly increased benefiting from Homology Indexing, there are still some chains of no satisfactory homologous template structures, such as PDB ID: 4h12, CHAIN ID: A. For this kind of protein chains, we further introduce Chain Length Indexing to reduce the number of time-consuming structural alignments.
Similar(59)
In a recent note Espirito Santo set a price target of 635p, but said that could be underestimation given the prospect of stronger UK economic growth boosting the business, as well as increased benefits from its efficiency drive.
Finally, the Caffeine for Apnea of Prematurity trial demonstrated increased benefit from caffeine on patients receiving higher levels of respiratory support that may lead to higher adenosine levels through increased lung injury (37).
Living in social groups provides several benefits such as better defense of food resources, less predation pressure and increased benefits from pooling information [1], [2].
It is not clear how these effects would translate into increased benefit from IIT.
ER-negative tumors exhibited significantly increased benefit from the above preoperative regimens compared to ER-positive tumors.
Several explanations for the increased benefit from tamoxifen in patients who carry a CYP2C19*2 allele can be considered.
Predictive biomarkers, or responder identification biomarkers, are molecules or other characteristics of a patient or a patient's malignancy that predict increased benefit from a particular drug.
In this study, we have shown a trend towards significance for an increased benefit from the addition of anthracycline in patients with high CIN.
These data correlate well with the clinical studies demonstrating increased benefit from tamoxifen therapy in those patients whose tumors are ERβ positive and suggest that this benefit may be through the actions of endoxifen.
Results from a retrospective phase III clinical trial conducted by the National Cancer Institute – Canada Group also confirm that Topo2 α protein overexpression might be associated with increased benefit from doxorubicin (hazard ratio 1.09, 95% CI: 1.03 1.15, P=0.002) (Durbecq et al, 2004).
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