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Some studies support an association between pre-obesity or obesity and increased attack frequency or chronic migraine [6,49,62].
Increased attack frequency may lead to the so-called 'chronic migraine' (CM), which becomes less responsive to both acute and prophylactic treatments.
Increased attack frequency can lead to the so-called 'chronic migraine' (CM), which then becomes less responsive to acute as well as prophylactic migraine medications [6].
Moreover, in MA+, but not in MA patients, it worsens progressively with time elapsed since the last migraine attack and decreases with increased attack frequency; in other words, VEP habituation increases with proximity to an attack.
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And, this risk of higher white matter lesion burden on MRI increased with increasing attack frequency [9].
10 years after onset the patient was hospitalized due to further worsening of the condition, with rapidly increasing attack frequency.
Moreover, some preliminary neuroimaging studies provided some evidence about increased risk of brain abnormalities with increasing attack frequency [5, 17, 21, 23] and disease duration [15, 17, 24] in migraineurs.
Since the patient was reluctant to stop verapamil because of fear increased CH attack frequency, we could not distinguish between both mechanisms prior to initiation of cabergoline treatment.
Indeed, RIA is associated with poor treatment outcomes (e.g., increased panic attack frequency).
Additionally, migraine with aura has been associated with a twofold increase in stroke risk [ 117], which appears to rise with increasing migraine attack frequency [ 118].
"There was this pattern of increasing attacks both in frequency and their distribution around the country," he said.
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