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His goal was to figure out if the pain of the Kavadi led to increased affinity for the temple.
However, changes in framework regions may have contributed to re-shaping the antibody paratopes leading to increased affinity.
Mchugh, L. et al. Increased Affinity and Stability of an Anti-HIV-1 Envelope Immunotoxin by Structure-based Mutagenesis *.
Affinity maturation favors the selection of the antibodies which exhibit increased affinity.
The imprinting process resulted in an increased affinity of the composites toward the corresponding template.
We used the switchSENSE approach31,32 (Fig. 3a) to investigate whether an oligonucleotide containing multiple tandem motifs would have increased affinity for the RBFOX1/2 RRM.
Locked nucleic acids (LNAs) demonstrate increased affinity and specificity for their cognate DNA sequences.
We then investigated whether an increase in the number of RBFOX1/2 motifs was associated with increased affinity to RBFOX1/2 RRM.
Our kinetic analyses of PKM2 WT) and PKM2(T365A) in cells show that active JNK1 increased affinity of PKM2 for ADP and PEP substrates.
Biomimetic dyes are expected to exhibit increased affinity and purifying ability for the targeted proteins.
The CBM16-1 Q121E mutatincreasedaffinityinity for all substrates tested, whereas the Q21G and N97R mutants exhibited decreased substrate affinity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com