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AAR ≥ 0.8 increased advanced fibrosis risk by a factor of 27.
To summarize, hyperglycemia leads to increased advanced glycosylation end products, commonly known as "AGEs".
Increased advanced glycation end products (AGEs) and oxidation products (OPs) are proposed to lead to progression of diabetic nephropathy (DN).
Consistent with this view, increased advanced glycation endproduct accumulation has been widely accepted to be a major cause of diabetic complications.
Increased advanced glycation end (AGE) products have been reported to be an important cause of increased osteoblast apoptosis in osteoporosis [ 1, 2].
Four mechanisms underlie the oxidative stress associated with hyperglycemia: increased polyol pathway flux, increased advanced glycation end product (AGE) formation, activation of protein kinase C (PKC) isoforms, and increased hexosamine pathway flux [ 15].
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Oxidative stress increases advanced glycation end product (AGE) accumulation and activation of Protein kinase C and the polyol pathway [12, 13].
The reason is that with the increasing advancing speed, the time of surface deformation continuously decreased, which speed up the recovery process of surface ground.
Standardized incidence rates of MM are increasing, advancing it to the second most common hematologic malignancy and accounting for 1 % of all cancers in the USA [ 2].
Reuters is reporting the government will increase advance payments of corporation tax and raise excise duties to make up for a suspension of a planned rise in sales tax.
With increasing advances and standards in the peri-operative care of patients, in-hospital complications are expected to be low.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com