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The downstream effect of increased PI3K is increased activation of the AKT pathway.
The R952Q variant of LRP8 increased activation of p38 mitogen-activated protein kinase by oxidized low-density lipoprotein.
Increased activation of MMP2 in turn activates proMMP9 [ 11].
Therefore, the increased expression of FasL is correlated with the increased activation of the NF-κB system.
However, in silico removal of MyD88 resulted in the increased activation of TRAM-dependent pathway compared to wildtype model, as illustrated by increased activation of TRAM, IRF3 and Cxcl10 (Figure 2A C, red).
The increased activation of SRC detected in tumor cells may therefore result from upstream activated RTKs [10].
Correlating with this subjective experience, MDMA evoked an increased activation of the visual cortex compared with placebo.
All of these effects are thought to be mediated by increased activation of serotonin receptors throughout the brain regions involved.
Beta-arrestin-2 inactivates Akt resulting in increased activation of GSK3.
GM-CSF treatment increased activation of alveolar macrophages, important for host defense function.
The increased activation of AMPKα in the colon was also detected in LC group.
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