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Site-directed mutant variants of these high CRES positions showed increased accumulation at 30 minutes as compared to that of WT-CaMdr1p and thus indicating a decrease in their ability to efflux NR, [3H] FLU and [3H] MTX.
In addition, note that immunostaining using MANDRA1 antibody, which recognizes a conserved epitope on both human and zebrafish Dystrophins, does not show increased accumulation at the ends of fibres containing huDysGFP compared with adjacent fibres lacking huDysGFP.
RADA combined with Scrapie results in an initial delay in detectable PrPsc followed by increased accumulation at later time points.
Data was in agreement with the data on picrosides content that showed its increased accumulation at 15°C.
As shown in Figure 6, all detected components showed increased accumulation at different level under MeJA induction.
The GM-CSF also can affect the migration of granulocytes (Gasson et al, 1984; Barker et al, 1991), resulting in their increased accumulation at tumour sites (Tseng et al, 1999).
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An increased accumulation of osteoclasts at the bone implant interface, impairment of osteoblast function, mechanical stresses and increased production of joint fluid contribute to bone resorption and subsequent loosening of the implant.
Verapamil increased accumulation of Rh123 at similar extent (ratio 2.87 : 526/183) compared to the CEM/A7R cells (ratio 2.90).
We also found in the present study that silencing of SlHUB1 or SlHUB2 led to increased accumulation of callose at the infection sites in the SlHUB1- or SlHUB2-silenced plants after infection of B. cinerea (Fig. 6c and d).
In the presence of sub-inhibitory concentrations of miconazole, the pdr16Δ cells displayed increased accumulation of lanosterol at the expense of the final product of the sterol biosynthetic pathway, ergosterol (Fig. 5B).
Studies on the transcriptional regulator of OpuA showed that the repressor of the opuA operon dissociates from the DNA at high ionic strengths, which is consistent with increased expression of the transporter and thus increased accumulation of glycine betaine at high osmotic stress [11].
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