Its incidence and prevalence increase with ageing.
89 90 Environmental illumination is inversely correlated with insomnia 42 91 and depression, 87 88 both of which increase with ageing.
Our finding indicated that extra caution should be taken when conducting exodontia in elderly patients receiving WF therapy, and the frequency of such situations would increase with ageing population.
Data on the chemokine RANTES/CCL5 are even less consistent: RANTES has been proposed as an ageing biomarker because its plasma concentrations have been shown to increase with ageing [ 39], but in our study we did not find any association with calendar age nor with clinical frailty.
In animals, oxidative stress increase with ageing due to high production of free radicals by aged mitochondria and decreased cellular antioxidant capacity.
Although it is a widely held belief that tissue levels of MMPs increase with ageing, more recent studies indicate that changes in MMP activity in most aged organs reflect a deregulation rather than pervasive increases (Reed et al, 2000).
