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Heparin treatment did not increase transfusion requirements.
Changes in the Medicare prospective payment system may increase transfusion rates.
Clopidogrel is a commonly used antiplatelet agent and has been shown to increase transfusion requirements in cardiac surgery [ 33, 34].
The majority favored an upper target of 10 g/dL, but a sizable proportion were willing to increase transfusion to levels exceeding 11g/dLL.
The authors used a one-sided statistical test to analyze the RBC transfusion data because "it was not expected that administration of rFVIIa would increase transfusion requirements".
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In addition, plasma-based blood products increase transfusion-associated acute lung injury, which affects lung clearance and patients receiving these blood products are prone to develop pneumonia; red blood cell transfusions also increase the rate of pneumonia [ 28].
Previous studies have not clearly demonstrated that thrombocytopenia results in increased mortality or increased transfusion requirements, however.
Anemia is not only very frequent among critically ill patients, it is also associated with increased transfusion rates and worse outcomes (increased length of stay, increased mortality) [ 6, 7].
More complex revision surgery and preoperative anemia are clearly associated with increased transfusion requirements and length of hospitalization.
Increased transfusion rates correlated with patient age, preoperative hemoglobin concentration, blood loss, and dual-component revision surgery.
Because of limited availability, costs and safety concerns related to blood transfusion, several strategies to reduce blood transfusions can be considered in addition to increasing transfusion trigger thresholds.
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