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Chemical modification of nucleic acids can greatly increase their functional diversity but access to the full phenotypic potential of such polymers requires a system of replication.
The objectives of our current study were to: introduce CO2 buffering to stabilize media pH in order to achieve long term culture within the system, incorporate sensors capable of recording high media oxygen concentrations, and to increase the culture time of bioengineered heart muscle within the perfusion system in order to increase their functional performance.
Progressive diversification of paralogs after gene expansion is essential to increase their functional specialization.
Another factor governing the length of regeneration time is how rapidly hepatocytes are able to increase their functional mass to compensate for lost tissue.
We determined how, in HT29, MA activates MAP kinases, including JNKs and thus p53, by which means they increase their functional activity.
Cajal body: Cajal bodies appear to be sites where proteins associated with a variety of nuclear processes concentrate to increase their functional efficiency, e.g. pre-assembly and modification of spliceosome components (Morris, 2008).
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We showed that exposure of bioengineered heart muscle to perfusion for a period of 24 h increased their functional performance, as measured by cellular viability, total protein, total RNA, spontaneous contractility, twitch force, and specific force.
Robert Bakker (1987) suggested that this would have allowed the shoulder blades to swing with the forelimbs in quadrupedal dinosaurs, increasing their functional forelimb length.
This analysis was performed separately for each participant, and the parameter estimates of the interaction term tested against zero at the population level using a one-tailed t-test to determine which voxels consistently increased their functional connectivity with the IFO during the disgust condition compared to the neutral condition.
For example, neighbouring grasses that share many traits may have increased their functional complementarity by associating with unique AMF.
We showed that cellular modifications greatly expand the chemical heterogeneity of these proteins, which, in turn, may increase their structural and functional diversity.
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