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Of the 52 patients taking alirocumab, 14 had to increase their dose midway through the trial because their cholesterol level had not dropped enough, Dr. Yancopoulos said.
Compared to the large number of prescriptions, relatively few individuals increase their dose on their own initiative or engage in drug-seeking behavior.
Those requiring hydrocortisone are usually instructed to increase their dose in physically stressful events such as injury, hospitalization and dental work as these are times when the normal supplementary dose may be inadequate, putting the patient at risk of adrenal crisis.
Women taking insulin would have been able to increase their dose of insulin to maintain glucose control, despite eating more.
We anticipated that when the lifeguards exercised they would increase their ventilation and effectively increase their dose of brevetoxin.
Participants will be instructed how to incorporate their supplement into their usual diet, and advised to gradually increase their dose over ten successive days until the target dose is reached.
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The recommendations, which modify guidelines set by the government only two and a half years ago, will increase by a few million the number of Americans who meet the criteria for therapy with the powerful cholesterol-reducing drugs called statins, and many people who are already taking the medications will be advised to increase their doses.
Farmers responded by increasing their dose, but the weeds became even more resistant.
The majority experienced dysphoric "withdrawal" symptoms in the "off" state and increased their dose of DRT in an effort to control their mood.
Increasing their dose would not lead to a gain in efficacy when the plateau is reached [23].
Nearly 60% of infliximab patients increased their dose at one year, compared to 18% for etanercept.
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