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The study suggests that NASA and other space agencies may need to worry that long manned missions will increase the virulence of microorganisms that astronauts inevitably carry with them.
Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae.
We also demonstrated that a selective pressure in artificial conditions can accidentally increase the virulence of a pathogen.
The insertion of either version of the HA ORF did not increase the virulence of the rNDV vector.
Previous studies showed that several mutations, such as P42S, D92E, and V149A, may increase the virulence of H5N1 viruses in pigs, mice and chickens, respectively [45], [46].
The association of E. coli NECS19923 and the S. mitis strain did not increase the virulence observed in the nematode model (LT50NECS19923+NSTRMIT 2.2 days) in comparison with the virulence obtained with E. coli alone (LT50NECS19923 2.1 days) (Fig. 1C).
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Furthermore, dietary trehalose increases the virulence of a RT027 strain in a mouse model of infection.
In some instances, temperature increases the virulence of the disease itself, by prompting viruses to multiply more.
In a paper published last month in PLos Pathogens, researchers in the Bassler lab revealed the existence of a new quorum sensing molecule that increases the virulence of Pseudomonas aeruginosa.
Molecular biology postdoc Sampriti Mukherjee and professor Bonnie Bassler recently discovered a new quorum-sensing molecule that increases the virulence of one particularly nasty bacterium, Pseudomonas aeruginosa, which has become resistant to antibiotics.
These findings show that the H201R replacement in Mga increases the virulence of M59 group A Streptococcus and provide new insight to how a naturally occurring SNP in bacteria contributes to human disease phenotypes.
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