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In contrast, the ability of TAK-779 to inhibit chemotaxis was hardly changed by mutation of the same five CXCR3 residues, with the H202A and Y308A7.43 mutations apparently increasing the IC50 values twofold when compared with WT CXCR3.
I became convinced that they would increase the resale value of my apartment at least twofold.
We've increased the gates twofold but been put through the mire for that.
RUNX1-CBFA2T1 siRNA treatment increased the doubling time twofold.
"You basically increase the size of a child twofold with a backpack," Mr. Russell said.
This project intends to increase the country's rise production and productivity by twofold.
"If you increase the temperature by 10 degrees, most times you can increase the reaction rate twofold," Zhang says.
"We look at the value as twofold," Mr. Tisch said.
C4S had the most prominent effect on the degradation of types I and II collagens by cathepsin K [ 41], whereas its effect on the hydrolysis of a synthetic substrate was virtually identical to that of C6S and DS and resulted in a twofold increase in the values of the specificity constant (kcat/ K m ).
On the other hand, the concentration of CEN1 HC killing ≥99% of the bacteria was increased only twofold comparing values at day 0 and 14 (from 6 to 12 mg/L for both S. aureus and MRSA), which is within the limits of assay variation.
In CaMKIIδC TG mice the heart weight/body weight ratio was increased by ~40% as compared to WT (Fig. 1a c, n = 13 vs. 14, P < 0.05) indicating an early stage of hypertrophy (8-week-old mice) since this value can increase to more than twofold in 3-month-old mice [ 16].
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