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It could also increase the targeting and efficacy of vaccines at low doses.
In addition, engineered Cpf1 variants with altered PAM specificities might replace wild type Cpf1, which can increase the targeting range of Cpf1-mediated genome regulation (Gao et al., 2017).
Although sgRNA expression is considered as the limiting factor for effective mutagenesis (Li et al. [2013b]), our result suggests that the accumulation of Cas9 could also increase the targeting efficiency.
At the same time, in order to further increase the targeting efficacy for fungal infections, we prepared anti-Candida albicans antibody (CDA -modified AMB-loaded PLGA-PLH-PEG nanopartiCDA -modified-NPs).
In the presence of Mg2+, addition of dNTPs did not significantly increase the targeting efficiency (not shown).
siRNAs used in the screen were designed using an algorithm developed to increase the targeting efficiency of the siRNA while reducing off-target silencing [35].
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The successful containment provides evidence for consideration of the use of foam to improve traditional flushing techniques, by increasing the targeting of contaminants by remedial agents.
Indeed, the integral binding avidity plays a predominant role in the targeting efficacy; the higher integral binding avidity increases the targeting efficacy.
Furthermore, overexpression of roX2 (but not roX1 ) in females using roX transgenes under a hsp83 promoter increased the targeting frequency.
He should hold more Burmese officials accountable by increasing the targeted sanctions list.
Ahead of the conference call we increase the target price to 680p (from 620p).
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