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This higher burden of chronic disease may both increase the predisposition to develop chronic illness and worsen outcomes.
A loss of SIRT4 function could therefore contribute to the development of diabetes due to higher levels of insulin that are known to increase the predisposition to both diabetes and other metabolic disorders (Katic and Kahn 2005).
Taken together, overall, it appears quite clear that β-adrenergic blocking agents can have an adverse effect on the outcome of an anaphylactic episode and perhaps can increase the predisposition toward these episodes.
An excess of oxidative stress, which is triggered by reactive oxygen species (ROS) or reactive nitrogen species (RNS), appears to increase the predisposition for glioma, as an elevated concentration of ROS/RNS can cause DNA damage, repress the activity of cellular enzymes, influence apoptosis and proliferation, and promote tumourigenesis [ 12, 13].
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The slow downhill motion of snow on the ground, referred to as snow gliding, impairs afforestation, increases the predisposition for landslides, fosters winter soil erosion, and coincides with the occurrence of glide-snow avalanches.
39 Fluctuations in CrCl can increase rivaroxaban plasma drug concentration increasing the predisposition to bleeding, especially in the elderly patient.
During our study, the most extreme drought in recorded history occurred in northern Arizona, thus increasing the predisposition for I. confusus outbreaks.
The present paper reviews studies that assessed association between genetic polymorphisms of genes encoding carcinogen-metabolizing enzymes and showed their possible involvement by significantly increasing the predisposition for HNC.
Playing tennis in hot ambient conditions for extended periods of time (1 3 h) increases the predisposition to exertional heat-illness, a potential health-threatening and performance-impairing condition, especially if fluid and electrolyte losses become excessive.
Furthermore, possibly common herd level factors may increase the animal level predisposition to several diseases.
Our results indicate that the AA genotype of ICAM-1 (rs5498) gene increases the risk predisposition for retinopathy in T2D patients in south Indian population.
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