Sentence examples for increase the imputation from inspiring English sources

Tuikkala and co-workers have investigated the interest to use GO annotation to increase the imputation accuracy of missing values [ 33] as Kim et al. [ 34].

Usage of a diverse reference population may increase the imputation accuracy of rare variants [ 50– 52], however, the computational burden also increases with the increase of the size of the reference population [ 31, 49].

A subset of them has been shared in the 1000 Bulls Genomes collaboration and in turn it was possible to increase the imputation reference with an additional 107 dairy bulls from run2 of the 1000 Bull Genomes reference data.

If exome chip data are available for previously genotyped samples, the combined approach using a genotype panel of merged data, including exome chips and SNP chips, should increase the imputation accuracy of rare variants.

The sires and dams of these animals were genotyped with the denser chip to increase the imputation accuracy; for simplicity, we considered a constant number of parents regardless of the genomic scenario, equal to the annual number of new breeding animals (900 gilts and 162 boars).

Increasing SNP density in the telomere regions of the chromosomes is expected to further increase the imputation performance of the customized chips [ 22].

Our study also provides a guideline for researchers to establish more cost-effective imputation strategies for increasing the imputation quality of rare variants.

Inclusion of very close relative in the reference group substantially increased the imputation accuracy especially when pedigree information was taken into account (Scenario C).

Moreover, a genotype panel combining exome chips and SNP chip data can help construct population-specific haplotypes carrying rare variants, thus also increasing the imputation accuracy of rare variants.

However, combining markers from several chromosomes did not increase the accuracy of imputation, which confirms that chromosomes are independent genetic and statistical units.

In this study, we propose a new strategy to increase the accuracy of imputation of rare variants by improving a new genotype panel by combining exome chip with existing SNP chip data.